Welcome to the CSLB
The Centre for Speech, Language and the Brain, headed by Professor Lorraine K Tyler, is part of the Department of Psychology at the University of Cambridge. Our interdisciplinary research covers a wide range of issues in the cognitive neuroscience of language, object processing, semantics, the ageing brain and cognition. We integrate behavioural experimental and neuroimaging studies on healthy people, together with similar research on brain-damaged patients.
The CSLB welcomes applications from postgraduate students for 2015 entry.
Given the interdisciplinary nature of our research, we particularly welcome applicants with a background in scientific computing, statistics, machine learning and/or signal processing methods. For more information click here.
News from the CSLB
- 17 August 2015
Young minds think alike - and older people are more distractible
A Cam-CAN study published today in the journal Neurobiology of Aging found that older people tended to be more easily distracted than younger adults. Age is believed to change the way our brains respond and how its networks interact, but studies looking at these changes tend to use very artificial experiments, with basic stimuli. To try to understand how we respond to complex, life-like stimuli, Cam-CAN showed 218 subjects aged 18-88 an edited version of an episode from the Hitchcock TV series while using functional magnetic resonance imaging (fMRI) to measure their brain activity. Our research team found a surprising degree of similarity in the thought patterns amongst the younger subjects – their brains tended to ‘light up’ in similar ways and at similar points in the programme. However, in older subjects, this similarity tended to disappear and their thought processes became more idiosyncratic, suggesting that they were responding differently to what they were watching and were possibly more distracted. The greatest differences were seen in the ‘higher order’ regions at the front of the brain, which are responsible for controlling attention (the superior frontal lobe and the intraparietal sulcus) and language processing (the bilateral middle temporal gyrus and left inferior frontal gyrus). Our findings suggest that our ability to respond to everyday events in the environment differs with age, possibly due to altered patterns of attention.
- 7 July 2015
Professor Tyler scoops second Advanced Investigator AwardProfessor Lorraine K. Tyler, Department of Psychology, has been awarded her second Advanced Investigator Award by the European Research Council. The prestigious ERC Advanced Grant funds exceptional established research leaders to pursue ground-breaking, high-risk projects that open new direction in their research fields. She is the only individual from the University of Cambridge to be awarded a second Advanced Grant under the 2014 call, and has the honour of being the second ever holder of two Advanced Grants within the University. The over €2million fund will support Professor Tyler’s LANGDYN (Language dynamics: a neurocognitive approach to incremental interpretation) research programme until October 2020. Her research aims to understand the complex processes and representations that support the transition of spoken language from auditory input to a meaningful interpretation, and the neurobiological systems in which they are instantiated. The novel research programme will combine advanced techniques from neuroimaging with new developments in multivariate statistics and computational linguistics to determine the nature of the processes involved in the transition from early perceptual analyses through different representational states to the development of a meaningful representation of an utterance, the dynamic spatio-temporal relationship between these processes, and their evolution over time.
- 20 April 2015
Professor Tyler featured in BNA Bulletin
"Through hearing, vision and our other senses, we constantly receive sensory inputs from the outside world. One of the brain's most remarkable properties is its ability to process and make sense of this information - to know that a series of auditory stimuli is someone asking us if we want a cup of tea, or that a complex visual input is a picture of a dog. Focusing on language and visual recognition of objects, Professor Lorraine K. Tyler in Cambridge is identifying some of the neural mechanisms underlying these remarkable feats."
Read the full article here. Reproduced with kind permission of the British Neuroscience Association.
- 09 February 2015
New publication in Neuropsychologia:
Paul Wright, Billi Randall, Alex Clarke, Professor Lorraine K. Tyler show how the perirhinal cortex (PRC) contributes to semantic cognition. The anterior temporal lobes (ATL) have become the focus of much research concerning the neurobiology of semantic memory. However the ATL is a large and diverse set of sub-regions, and so understanding the functioning of the ATL requires investigations that test between different sub-regions. Here, we show that the PRC, in the medial aspects of the ATL, provides a critical function for the disambiguation between semantically confusable concepts (e.g. a lion and a tiger). By comparing individuals with brain-damage including the PRC - and other ATL sub-regions, against two control groups, we show that damage to the PRC results in impaired performance in identifying concepts that are more semantically confusable. This was shown using a number of different measures of semantic confusability and different tasks. Critically, we also show that an individuals’ degree of impairment was correlated with the extent of damage to the PRC, which was not consistently seen for other sub-regions. These results provide important converging evidence for the role of the human PRC in semantic cognition in supporting fine-grained semantic distinctions between concepts.
Check out the journal website.
Major themes cross-cutting our research
Neurobiology of spoken language in healthy and brain-damaged populations:
- Working with healthy people, we develop accounts of the functional relationships between the anatomically distributed regions involved in language processing.
- Working with brain-damaged patients (in both the acute and chronic phases), we investigate issues of reorganisation and plasticity following brain damage.
Neurocognitive accounts of conceptual knowledge:
- How is meaning represented and processed in the mind and brain? We develop cognitive models of conceptual knowledge and investigate how conceptual knowledge is processed in both the healthy and damaged system.
The ageing brain and cognition:
- We study language function in normal healthy ageing to determine the relationship between preserved function and neural change.
Major new study in brain ageing (Cam-CAN)
Research efforts to understand how the brain changes with age, from early to late adulthood, have been given a major boost by a new £5M grant from the BBSRC. The funding has been awarded to a team of scientists from the University of Cambridge Departments of Psychology, Public Health, Psychiatry, Clinical Neurosciences and Engineering, and from the MRC Cognition and Brain Sciences Unit. This team, working as the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), brings together world-leading expertise and cutting edge methods to understand how brain ageing in healthy people affects abilities like language, attention, emotion and memory.
The ageing process does not have a uniform effect across the brain. Older people often struggle, for example, to recall the right word in a conversation, but can continue to expand their vocabulary throughout old age. Understanding what structures in the brain account for this variation will be a crucial first step in allowing more people to retain a range of mental abilities throughout their lives. Professor Lorraine K Tyler, who heads the research team, said "Our mental abilities don't suddenly start to decline as we enter retirement. In fact, many are retained right into our eighties and we are often too quick to attribute normal lapses like forgetfulness to the effects of age. Understanding the complexities of how ageing affects the brain will be crucial for older people to be able to live fulfilled lives and contribute fully to society."
The study is unique in recruiting 3000 people aged 18-88 years, drawn from the general population, to create a library of information on how healthy brain ageing affects mental abilities to different degrees. Not only will this help identify older people who might be helped by therapies, but will also provide a lasting resource for future researchers to draw on. The research will establish a virtual "brain and behaviour" database which will hold behavioural, MRI and MEG data from a population-representative sample of 700 healthy adults. This will be a valuable, open-access resource for scientists interested in ageing, and a basis for longitudinal study of how our brain and our cognitive abilities change as we grow older.
ERC Advanced Investigator grant
An ERC Advanced Investigator Grant has been awarded to Professor Lorraine K Tyler. This 5-year programme will support her research programme 'PERCEPCON', investigating how the brain processes visual inputs as meaningful objects.
More about us
The Centre is directed by Professor Lorraine K Tyler, Professor of Cognitive Neuroscience and Fellow of Clare College. Researchers at the CSLB come from various academic fields such as cognitive psychology, neuroscience, linguistics, cognitive science, and computer science. We collaborate with scientists at the Department of Psychiatry, the Department of Clinical Neurosciences, the Behavioural and Clinical Neuroscience Institute, the MRC Cognition and Brain Sciences Unit, the Wolfson Brain Imaging Centre, Johns Hopkins University, Pomona College, and University Hospital Basel.
The Centre, formerly called the Centre for Speech and Language, is/has recently been funded by grants from
- Medical Research Council (MRC)
- Biotechnology and Biological Sciences Research Council(BBSRC) Strategic Longer and Larger Grant
- European Research Council Advanced Investigator Grant
- Dunhill Medical Trust
- Engineering and Physical Sciences Research Council (EPSRC)
- Isaac Newton Trust
- Research into Ageing
- British Academy
- EC FP6 Marie Curie Fellowship
- Economic and Social Research Council (ESRC)